منابع مشابه
Genetic Insights into Sporadic Parkinson's Disease Pathogenesis
Intensive research over the last 15 years has led to the identification of several autosomal recessive and dominant genes that cause familial Parkinson's disease (PD). Importantly, the functional characterization of these genes has shed considerable insights into the molecular mechanisms underlying the etiology and pathogenesis of PD. Collectively; these studies implicate aberrant protein and m...
متن کاملGenetic insights into disease mechanisms of autoimmunity.
Educating the immune system to distinguish between self and non-self is critical to ensure that an immune response is mounted against foreign antigens and not against self. A breakdown in these mechanisms can lead to the onset of autoimmune disease. Clinical and molecular data suggest that shared immunogenetic mechanisms lead to the autoimmune process. The most studied genes and molecules are t...
متن کاملPaediatric stroke: genetic insights into disease mechanisms and treatment targets.
In children, stroke is as common as brain tumour and causes substantial mortality and long-term morbidity, with recurrence in up to 20%. There are three sets of international clinical guidelines relating to childhood stroke; however, acute and preventive treatment recommendations are based on interventions effective in adults, rather than data regarding efficacy in children. A wide spectrum of ...
متن کاملDopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
OBJECTIVES To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease. METHODS A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index...
متن کاملInsights into Behçet’s disease
Behçet’s disease is a chronic relapsing multi-organ inflammatory disorder characterized as a triad of oral and genital ulcers, uveitis. Characteristic manifestations of Behçet’s disease are joints, skin, central nervous system and gastrointestinal tract involvement. Behçet’s disease has a complicated genetic etiology. However, epidemiological studies recommend that genetic factors have a signif...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Progress in Neurology and Psychiatry
سال: 2008
ISSN: 1367-7543,1931-227X
DOI: 10.1002/pnp.55